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教师名录

戴隆海

作者:生命科学学院发布时间:2023年01月07日 13:51

一、基本信息

戴隆海,博士,副教授,博士生导师

电子邮件:dailonghai(at)hubu.edu.cn

研究领域:生物催化与酶工程、酶结构与催化机理

二、工作经历

2019.07至今         湖北大学,省部共建生物催化与酶工程国家重点实验室,副教授

2018.10–2020.10  湖北大学,材料科学学院,博士后

2016.07–2018.09  中国科学院天津工业生物技术研究所,工业酶国家工程实验室,助理研究员

三、学习经历

2013.09–2016.07  中国科学院天津工业生物技术研究所,博士

2010.09–2013.03  天津科技大学,硕士

2006.09–2010.07  南昌大学,学士

四、主持科研项目

1. 湖北省自然科学杰出青年基金,30万,2022.102025.09, 主持

2. 国家重点研发计划之子课题,144.5万,2021.072024.06子课题负责人

3. 国家自然科学青年基金,22万,2018.012020.12, 主持

4. 中国博士后基金面上资助(第66批),8万,2019.072020.08,主持

5. 湖北省博士后创新研究岗(第1批),6万,2019/7-2020/8,主持

五、代表性论文(#第一作者; *通讯作者)

1. Dai, L.,# Li H.,# Huang, J.W.,# Hu, Y.,# He, M., Yang, Y., Min, J., Chen C.C.,* Guo, R.T.* Structure–based rational design of a short–chain dehydrogenase/reductase for improving activity toward mycotoxin patulin. International Journal of Biological Macromolecules, 2022. 222, 421-428.

2. Li H.,# Yang Y.,# Hu Y.,# Chen, C.C., Huang, J.W., Min, J., Dai, L.,* Guo, R.T.* Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona. Journal of Hazardous Materials, 2022. 129191.

3. Dai, L.,# Zhang, X.,# Hu Y,# Shen, J., Zhang, Q., Zhang, L., Min, J., Chen C.C., Liu, L.,* Huang, J.W.,* Guo, R.T.* Structural and functional insights into a nonheme iron- and α-ketoglutarate-dependent halogenase that catalyzes chlorination of nucleotide substrates. Applied and Environmental Microbiology, 2022. 88(9). e02497-21.

4. Hu, Y.,# Li, H.,# Min, J.,#, Yu, Y., Liu, W, Huang, J.W., Zhang, L., Yang, Y., Dai, L.,* Chen C.C.,* Guo, R.T.* Crystal structure and biochemical analysis of the specialized deoxynivalenol–detoxifying glyoxalase SPG from Gossypium hirsutum. International Journal of Biological Macromolecules, 2022, 200, 388-396.

5. Chen, C.C.,# Han, X.,# Li, X.,# Jiang, P., Niu, D., Ma, L., Liu, W., Li, S., Qu, Y., Hu, H., Min, J., Yang, Y., Zhang, L., Zeng, W., Huang, J.W.,* Dai, L.,* Guo, R.T.* General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis. Nature Catalysis, 2021, 4, 425-430.

6. Dai, L.,# Qu, Y.,# Hu Y,# Min J, Yu X., Chen, C.C., Huang, J.W.,* Guo, R.T.* Catalytically inactive lytic polysaccharide monooxygenase PcAA14A enhances the enzyme-mediated hydrolysis of polyethylene terephthalate. International Journal of Biological Macromolecules, 2021, 190, 456-462.

7. Dai, L., Hu, Y., Chen, C.C., Ma, L.,* Guo, R.T.* Flavonoid C-glycosyltransferases: function, evolutionary relationship, catalytic mechanism and protein engineering. ChemBioEng Reviews, 2021, 8(1), 15-26.

8. Dai, L.,# Qu, Y.,# Huang, J.W., Hu, Y., Hu, H., Li, S., Chen C.C.,* Guo, R.T.* Enhancing PET hydrolytic enzyme activity by fusion of the cellulose-binding domain of cellobiohydrolase I from Trichoderma reesei. Journal of Biotechnology, 2021, 334: 47-50.

9. Dai, L.,# Liu, C.,# Li, J., Dong, C., Yang, J., Dai, Z., Zhang, X.,* Sun, Y.* One-pot synthesis of ginsenoside Rh2 and bioactive unnatural ginsenoside by coupling promiscuous glycosyltransferase from Bacillus subtilis 168 to sucrose synthase. Journal of Agricultural and Food Chemistry, 2018, 66: 2830-2837.

10. Dai, L., Li, J., Yang, J., Zhu, Y., Men, Y., Zeng, Y., Cai, Y., Dong, C., Dai, Z., Zhang, X.*, Sun, Y.* Use of a promiscuous glycosyltransferase from Bacillus subtilis 168 for the enzymatic synthesis of novel protopanaxatriol-type ginsenosides. Journal of Agricultural and Food Chemistry, 2018, 66: 943-949.

六、申请与授权专利

1. 孙媛霞,戴隆海,张学礼,戴柱波,李娇;一组天然与非天然的原人参三醇型人参皂苷的合成方法;授权号:ZL201711155328.0,中国专利。

2. 孙媛霞,戴隆海,李娇,杨建刚,门燕;一种非天然人参皂苷Rd12及其制备方法和应用;授权号:ZL201711146324.6,中国专利

3. 孙媛霞,戴隆海,张学礼,戴住波,李娇;一种非天然人参皂苷的制备方法及应用;授权号:ZL201711146314.2,中国专利

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