一、基本信息
邵雄俊，博士，教授，博士生导师
电子邮件：xiongjun_shao(AT)hotmail.com
研究领域：木质纤维素（如秸秆）生物转化，微生物代谢工程
研究方向：生物能源，生物基化学品
二、教育背景
2001.09 – 2007.03 美国达特茅斯学院，生物工程，博士
2005.09 – 2006.12 美国达特茅斯学院，工程管理，硕士
1996.09 – 2001.07 大连理工大学，化工工艺，学士
1996.09 – 2001.07 大连理工大学，英语，学士
三、工作经历
2017.08至今 湖北大学生命科学学院，教授
2013.09–2017.07 美国能源部生物能源科学中心，项目负责人（兼）
2011.11–2017.07 美国达特茅斯学院，研究助理教授
2010.02–2010.10 美国达特茅斯学院，研究科学家
2007.04–2010.01 美国达特茅斯学院，博士后
四、科研项目
1. 纤维原料水解发酵制取化学品及功能糖提纯技术，横向，2021-2024，主持
2. 纤维原料水解制糖技术，横向，2021-2023，主持
3. 纤维原料制取生物乙醇技术，横向，2019-2021，主持
4. Biomass Cotreatment，USDA，2016-2019，共同主持
5. BioEnergy Science Center，USDOE，2012-2017，共同主持
五、发表论文（#共同一作）
1. Shao X, Murphy SJ, Lynd LR. (2020) Characterization of reduced carbohydrate solubilization duringClostridium thermocellumfermentation with high switchgrass concentrations.Biomass and Bioenergy139, 105623.
2. Liang X, Whitham JM, Holwerda EK,Shao X, Tian L, Wu Y-W, Lombard V, Henrissat B, Klingemann DM, Yang ZK, Podar M, Richard TL, Elkins JG, Brown SD, Lynd LR. (2018) Development and characterization of stable anaerobic thermophilic methanogenic microbiomes fermenting switchgrass at decreasing residence times.Biotechnology for Biofuels11, 243.
3. Zhou J#,Shao X#, Olson DG, Murphy SJ, Tian L, Lynd LR. (2017) Determining the roles of the three alcohol dehydrogenases (AdhA, AdhB and AdhE) inThermoanaerobacter ethanolicusduring ethanol formation.Journal of Industrial Microbiology and Biotechnology44, 745–757.
4. Zheng T, Olson DG, Murphy SJ,Shao X, Tian L, Lynd LR. (2016) Both adhE and a separate NADPH-dependent alcohol dehydrogenase (adhA) are necessary for high ethanol production inThermoanaerobacterium saccharolyticum.Journal of Bacteriology. 199, e00542-16.
5. Tian L, Lo J, Shao X, Zheng T, Olson DG, Lynd LR. (2016) Identification of a ferredoxin: NAD+oxidoreductase enzyme inThermoanaerobacterium saccharolyticumand its role in ethanol formation.Applied and Environmental Microbiology82, 7134–7141.
6. Shao X, Zhou J, Olson DG, Lynd LR. (2016) A markerless gene deletion and integration system forThermoanaerobacter ethanolicus.Biotechnology for Biofuels9, 100.
7. Shao X, DiMarco K, Richard TL, Lynd LR. (2015) Winter rye as a bioenergy feedstock: impact of crop maturity on composition, biological solubilization and potential revenue.Biotechnology for Biofuels8,35
8. Archambault-Leger V,Shao X, and Lynd LR. (2014) Simulated performance of reactor configurations for hot-water pretreatment of sugarcane bagasse.ChemSusChem7, 2721–2727.
9. St Brice LA,Shao X, Izquierdo JA, Lynd LR. (2014) Optimization of affinity digestion for the isolation of cellulosomes fromClostridium thermocellum.Preparative Biochemistry & Biotechnology44, 206–216.
10. Shao X, Lynd LR. (2013) Kinetic modeling of xylan hydrolysis in co- and countercurrent liquid hot water flow-through pretreatments.Bioresource Technology130, 117–124.
11. Archambault-Leger V,Shao X, Lynd LR. (2012) Integrated analysis of hot water flowthrough pretreatment.Biotechnology for Biofuels5, 49.
12. Ellis LD, Holwerda EK, Hogsett D, Rogers S, Shao X, Tschaplinski T, Thorne P, and Lynd LR. (2012) Closing the carbon balance for fermentation byClostridium thermocellum(ATCC 27405).Bioresource Technology103, 293–299.
13. Shao X, Raman B, Zhu M, Mielenz JR, Brown SD, Guss AM, and Lynd LR. (2011). Mutant selection and phenotypic and genetic characterization of ethanol-tolerant strains ofClostridium thermocellum.Applied Microbiology and Biotechnology92, 641–652.
14. Brown S.D., Guss AM, Karpinets TV, Parks JM, Smolin N, Yang S, Land ML, Klingeman DM, Bhandiwad A, Rodriguez M, Raman B,Shao X, Mielenz JR, Smith JC, Keller M, and Lynd LR. (2011) Mutant alcohol dehydrogenase leads to improved ethanol tolerance inClostridium thermocellum.Proceedings of the National Academy of Sciences of the United States of America108, 13752–13757.
15. Shao X, Jin M, Guseva A, Liu C, Balan V, Hogsett D, Dale B, Lynd L. (2011) Conversion for Avicel and AFEX pretreated corn stover byClostridium thermocellumand simultaneous saccharification and fermentation: Insights into microbial conversion of pretreated cellulosic biomass.Bioresource Technology102, 8040–8045.
16. Podkaminer K,Shao X, Hogsett D, Lynd L. (2011) Enzyme inactivation by ethanol and development of a kinetic model for thermophilic simultaneous saccharification and fermentation at 50°C withThermoanaerobacterium saccharolyticumALK2.Biotechnology and Bioengineering108, 1268–1278.
17. Shao X, Lynd L, Bakker A, LaRoche R, and Wyman C. (2010) Reactor scale up for biological conversion of cellulosic biomass to ethanol.Bioprocess and Biosystems Engineering33,485–493.
18. Shao X, Lynd L, Wyman C, Bakker A. (2009) Kinetic modeling of cellulosic biomass to ethanol via simultaneous saccharification and fermentation: Part I. Accommodation of intermittent feeding and analysis of staged reactors.Biotechnology and Bioengineering102, 59–65.
19. Shao X, Lynd L, Wyman C. (2009) Kinetic modeling of cellulosic biomass to ethanol via simultaneous saccharification and fermentation: Part II. Experimental validation using waste paper sludge and anticipation of CFD analysis.Biotechnology and Bioengineering102, 66–72.
20. Zhang J,Shao X, Townsend O, Lynd L. (2009) Simultaneous saccharification and co-fermentation of paper sludge to ethanol bySaccharomyces cerevisiaeRWB222 - Part I: Kinetic modeling and parameters.Biotechnology and Bioengineering104, 920–931.
21. Zhang J,Shao X, Lynd L. (2009). Simultaneous saccharification and co-fermentation of paper sludge to ethanol bySaccharomyces cerevisiaeRWB222 - Part II. Investigation of discrepancies between predicted and observed performance at high solid concentration.Biotechnology and Bioengineering104, 932–938.
